Hydrastis canadensis root, an endangered woodland herb exceptionally rich in isoquinoline alkaloids including berberine, hydrastine, and canadine. Goldenseal acts as a powerful broad-spectrum antimicrobial, preventing bacterial and protozoan adhesion to mucous membranes and toning inflamed mucosal linings.
Educational information only — never stop or change a prescribed medication without talking to your prescriber first.
Use for short durations (up to 10-14 days). CONTRAINDICATED during pregnancy and lactation (berberine can cross placenta and enter breast milk, risking kernicterus in neonates). May inhibit CYP3A4 and CYP2D6 enzymes.
Evidence level: Strong
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