Sarsaparilla (Smilax ornata or Smilax regelii) is a climbing vine native to Central and South America whose root has been used for centuries by indigenous peoples and later in Western herbal medicine. It gained fame as a 'blood purifier' and treatment for syphilis in the 16th century. Today it is used primarily for its anti-inflammatory, antioxidant, and skin-clearing properties. It contains plant sterols like sarsasaponin and sitosterol which may support hormonal balance.
Educational information only — never stop or change a prescribed medication without talking to your prescriber first.
May cause stomach irritation in high doses. Can interact with diuretics, lithium, and medications metabolized by the liver (CYP3A4 pathway). Some preparations may be contaminated — always purchase from reputable sources. Avoid during pregnancy and breastfeeding without medical supervision. Not a substitute for treatment of serious infections.
Evidence level: Moderate
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