Hypericum perforatum flowers contain hyperforin and hypericin. Hyperforin acts as a broad-spectrum monoamine reuptake inhibitor, increasing synaptic concentrations of serotonin, dopamine, norepinephrine, GABA, and L-glutamate, effectively elevating mood and relieving neurogenic pain.
Educational information only — never stop or change a prescribed medication without talking to your prescriber first.
MAJOR DRUG INTERACTIONS: Potently induces cytochrome P450 3A4 (CYP3A4) and P-glycoprotein, drastically lowering blood levels of oral contraceptives (birth control), immunosuppressants (cyclosporine), anticoagulants (warfarin), and HIV medications. NEVER combine with prescription antidepressants due to risk of Serotonin Syndrome. May cause photosensitivity.
Evidence level: Strong
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