A perennial shrub containing petasins (petasin and isopetasin) that exert potent anti-spasmodic and anti-inflammatory actions by blocking leukotriene synthesis and L-type calcium channels. It is clinically established for migraine prophylaxis and allergic rhinitis.
Educational information only — never stop or change a prescribed medication without talking to your prescriber first.
MUST strictly use certified Pyrrolizidine Alkaloid-Free (PA-free) formulations to prevent irreversible liver damage and hepatotoxicity. Avoid in patients with Asteraceae/ragweed allergies. Contraindicated during pregnancy and lactation.
Evidence level: Strong
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