A medicinal daisy traditionally used to reduce the frequency, duration, and severity of migraine headaches and lower fevers. Its primary sesquiterpene lactone, parthenolide, inhibits platelet aggregation, serotonin release, and pro-inflammatory prostaglandin synthesis.
Educational information only — never stop or change a prescribed medication without talking to your prescriber first.
Can cause aphthous mouth ulcers and gastrointestinal upset if fresh leaves are chewed. Abrupt discontinuation after chronic use can cause 'post-feverfew syndrome' (rebound headaches, anxiety, insomnia). Contraindicated during pregnancy and with blood thinners.
Evidence level: Strong
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