A potent isoquinoline alkaloid extracted from Berberis aristata, Coptis chinensis, and Hydrastis. Berberine is a master activator of AMP-activated protein kinase (AMPK), the 'metabolic master switch', stimulating glucose uptake via GLUT4, improving insulin sensitivity, increasing LDL receptor expression in the liver, and restoring gut microbiome balance.
Educational information only — never stop or change a prescribed medication without talking to your prescriber first.
Inhibits cytochrome P450 enzymes (CYP3A4, CYP2D6); check for interactions with prescription drugs. May cause mild gastrointestinal cramping, constipation, or diarrhea when first initiated. CONTRAINDICATED during pregnancy and breastfeeding.
Evidence level: Strong
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