Uncaria tomentosa, an Amazonian woody vine containing pentacyclic oxindole alkaloids (POAs) and quinovic acid glycosides. Cat's Claw inhibits NF-kB transcription factor activation, suppressing TNF-alpha and PGE2 production, relieving inflammatory joint pain and supporting cellular DNA repair.
Educational information only — never stop or change a prescribed medication without talking to your prescriber first.
Ensure use of POA-chemotype (tetracyclic oxindole alkaloids / TOAs can counteract benefits). Contraindicated during pregnancy, before organ transplant, and in individuals on immunosuppressants due to immune-modulating effects.
Evidence level: Strong
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