HerbsRx
Strong evidence

Cat's Claw

Uncaria tomentosa, an Amazonian woody vine containing pentacyclic oxindole alkaloids (POAs) and quinovic acid glycosides. Cat's Claw inhibits NF-kB transcription factor activation, suppressing TNF-alpha and PGE2 production, relieving inflammatory joint pain and supporting cellular DNA repair.

What Cat's Claw is used for

  • Osteoarthritis
  • Rheumatoid Arthritis
  • Chronic Joint Pain
  • Immune Modulation
  • Lyme Disease Support
  • Gut Inflammation

Pharmaceuticals Cat's Claw is studied as a natural alternative to

  • Advil
  • Celebrex
  • Plaquenil
  • Methotrexate (supportive)
  • Immunomodulators

Educational information only — never stop or change a prescribed medication without talking to your prescriber first.

Safety and warnings

⚠️

Ensure use of POA-chemotype (tetracyclic oxindole alkaloids / TOAs can counteract benefits). Contraindicated during pregnancy, before organ transplant, and in individuals on immunosuppressants due to immune-modulating effects.

Evidence level: Strong

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