Barberry (Berberis vulgaris) is a deciduous shrub containing the high-potency isoquinoline alkaloid berberine in its roots and bark. Berberine is a powerful broad-spectrum antimicrobial agent that inhibits the growth of pathogens, including bacteria, fungi, and protozoa, by disrupting cell membrane integrity. It also activates AMP-activated protein kinase (AMPK) to improve insulin sensitivity and stimulates bile secretion to relieve gallbladder congestion.
Educational information only — never stop or change a prescribed medication without talking to your prescriber first.
CRITICAL: Do not use during pregnancy or lactation, as berberine can cause uterine contractions and may cross the placenta to cause kernicterus in newborns. High doses may cause gastrointestinal discomfort or constipation.
Evidence level: Moderate
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